Establishment of an oral infection model resembling the periodontal pocket in a perfusion bioreactor system
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Establishment of an oral infection model resembling the periodontal pocket in a perfusion bioreactor system
Periodontal infection involves a complex interplay between oral biofilms, gingival tissues and cells of the immune system in a dynamic microenvironment. A humanized in vitro model that reduces the need for experimental animal models, while recapitulating key biological events in a periodontal pocket, would constitute a technical advancement in the study of periodontal disease. The aim of this s...
متن کاملProteomic profiling of host-biofilm interactions in an oral infection model resembling the periodontal pocket
Periodontal infections cause inflammatory destruction of the tooth supporting tissues. We recently developed a dynamic, in vitro periodontal organotypic tissue model in a perfusion bioreactor system, in co-culture with an 11-species subgingival biofilm, which may recapitulate early events during the establishment of periodontal infections. This study aimed to characterize the global proteome re...
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ژورنال
عنوان ژورنال: Virulence
سال: 2015
ISSN: 2150-5594,2150-5608
DOI: 10.4161/21505594.2014.978721